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Introduction to Molecular Biology: Universal Features of Cells

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What Molecular Biology Studies & The Three Domains of Life

Molecular biology studies how molecules interact with one another in living organisms to perform the functions of life.


Life started ~3.5 billion years ago. All life is organized into three major domains (based on genome comparisons):


DomainNucleus?Cell typeExamples
Bacteria (Eubacteria)NoProkaryoteE. coli, Salmonella, Cyanobacteria
ArchaeaNoProkaryoteAsgard archaea
EukaryotaYesEukaryoteAnimals, plants, fungi

  • Prokaryotes = NO nucleus; Eukaryotes = HAVE a nucleus (the defining distinction).
  • Two key endosymbiosis events shaped eukaryotes: mitochondrial symbiosis and chloroplast symbiosis.
  • Insects dominate known species diversity (~1.05 million of ~2.15 million total).